Document Detail

Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.
MedLine Citation:
PMID:  23039796     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atopic dermatitis (AD) and loss-of-function mutations in the filaggrin gene (FLG) are both associated with chronic irritant contact dermatitis (ICD). As FLG mutations also are a major risk factor for AD, it is not clear whether FLG mutations are an independent risk factor for ICD or whether the risk is mediated by AD.
OBJECTIVES: To investigate the relative contribution and interaction of FLG mutations and AD in German patients with occupational ICD and controls (vocational school apprentices).
METHODS: A total of 634 patients and 393 controls were genotyped for R501X, 2282del4, R2447X and S3247X. Current or past flexural eczema was used as an indicator of AD.
RESULTS: FLG mutations were found in 15·9% of the patients with ICD and 8·3% of the controls, with a crude odds ratio (OR) of 2·09 [95% confidence interval (CI) 1·33-3·28] for the combined genotype. The adjusted OR for FLG mutations, corrected for AD, was 1·62 (95% CI 1·01-2·58). Subjects with AD were at approximately three times higher risk of developing ICD than controls (OR 2·89; 95% CI 2·09-3·99). There was no evidence of an interaction between these two risk factors.
CONCLUSIONS: Our results indicate that both FLG mutations and AD increase the risk of ICD. Individuals with concurrent FLG mutations and AD are at the highest risk of developing ICD.
M J Visser; L Landeck; L E Campbell; W H I McLean; S Weidinger; F Calkoen; S M John; S Kezic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  168     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-18     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  326-32     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
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MeSH Terms
Age of Onset
Dermatitis, Atopic / genetics*
Dermatitis, Irritant / genetics*
Dermatitis, Occupational / genetics*
Genetic Predisposition to Disease / genetics
Intermediate Filament Proteins / genetics*
Middle Aged
Mutation / genetics*
Risk Factors
Grant Support
090066//Wellcome Trust; 090066 ⁄B ⁄09 ⁄ Z//Wellcome Trust; 092530//Wellcome Trust; 092530 ⁄ Z ⁄10 ⁄Z//Wellcome Trust; G0700314//Medical Research Council; G0700314//Medical Research Council
Reg. No./Substance:
0/Intermediate Filament Proteins; 0/filaggrin
Comment In:
Br J Dermatol. 2013 Feb;168(2):233-4   [PMID:  23362965 ]

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