| Impact of Islet Transplantation on Diabetes Complications and Quality of Life. | |
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MedLine Citation:
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PMID: 21748256 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Insulin represents a life-saving therapy for patients with type 1 diabetes but, despite appropriate treatment, it prevents only partially long-term diabetic complications, while generating fatal hypoglycemic episodes. Islet transplantation gained attention because of its safety, effectiveness, and minimal invasiveness; however it remains a procedure reserved for a selected group of patients. The introduction of the Edmonton Protocol in 2000, based on a newly designed steroid-free immunosuppressive protocol, revamped the course of islet transplantation. The main goal of islet transplantation remains insulin independence, although the effect of islet transplantation can be more comprehensively evaluated in terms of frequency of hypoglycemic episodes and impact on diabetic complications and quality of life. Islet transplantation was shown to have positive consequences on cardiovascular, renal, neurologic, and ocular diabetic complications. The proof of concept for cellular replacement therapy in diabetes has been established with islet transplantation, it only needs to be improved and rendered widely available. |
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Authors:
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Roberto Bassi; Paolo Fiorina |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-12 |
Journal Detail:
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Title: Current diabetes reports Volume: - ISSN: 1539-0829 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Transplantation Research Center, Nephrology Division, Children's Hospital/Harvard Medical School, 300 Longwood Avenue, Enders Building EN530, Boston, MA, 02115, USA, bassi.roberto@hsr.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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