| Impact of insulin-treated diabetes and hemodialysis on long-term clinical outcomes following sirolimus-eluting stent deployment. Insights from a sub-study of the Cypher Stent Japan Post-Marketing Surveillance(Cypher J-PMS) Registry. | |
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MedLine Citation:
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PMID: 21041974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Long-term clinical outcomes of diabetes mellitus (DM) patients who underwent drug-eluting stent deployment has not well investigated. METHODS AND RESULTS: A total of 2,050 cases were enrolled consecutively from 50 sites in Japan into the Cypher stent Japan Post-Marketing Surveillance (Cypher J-PMS) registry, and the 3-year outcomes of DM patients were analyzed. Subjects were divided into 2 groups based on the treatment of DM (insulin-treated diabetes (IT) group, n=207; and non insulin-treated diabetes (NIT) group, n=682). Major adverse cardiac event (MACE) rates in the IT group and the NIT group were 26.0% and 14.5% at 3 years, respectively (P<0.001). There were no significant differences in stent thrombosis rates (definite and probable by Academic Research Consortium (ARC) definition) (0% and 1.08%, respectively). Multivariate analysis suggested that hemodialysis and insulin-treated DM were independent predictors for MACE, and insulin-treated DM, hemodialysis and long lesions were strong independent predictors for target-lesion revascularization (TLR). CONCLUSIONS: Hemodialysis and insulin-treated DM were strong independent predictors of mortality and TLR in DM patients. These results might suggest that special attention to patients with hemodialysis and insulin-treated DM is warranted in the setting of sirolimus-eluting stent deployment for DM patients. |
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Authors:
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Masato Nakamura; Hiroyoshi Yokoi; Yuji Hamazaki; Masato Watarai; Mikihiro Kijima; Kazuaki Mitsudo; |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-10-28 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-03-09 Revised Date: 2012-01-09 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 2592-7 Citation Subset: IM |
Affiliation:
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Toho University Ohashi Medical Center, Tokyo, Japan. masato@oha.toho-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Diabetes Complications / mortality*, therapy Drug-Eluting Stents* Female Follow-Up Studies Heart Diseases / etiology, mortality*, therapy Humans Hypoglycemic Agents / administration & dosage* Immunosuppressive Agents / pharmacology* Insulin / administration & dosage* Japan Male Middle Aged Product Surveillance, Postmarketing Registries* Renal Dialysis* Sirolimus / pharmacology* Thrombosis / etiology, mortality* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Immunosuppressive Agents; 0/Insulin; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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