| The Impact of Insulin Resistance and Inflammation on the Association between Sarcopenic Obesity and Physical Functioning. | |
| | |
MedLine Citation:
|
PMID: 22310233 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Age associated increases in visceral adiposity and decreases in muscle mass (sarcopenia) have been shown to contribute to disability in late life. Furthermore, there is evidence that obesity-related physiological states, such as insulin resistance and systemic inflammation, may exacerbate physical functioning problems. Both conditions have been shown to prompt hypercatabolism and impair the anabolic effect of muscles, ultimately stimulating protein breakdown and suppressing muscle synthesis. This cross-sectional study investigates whether insulin resistance and inflammation partially account for the associations between decreased physical functioning and sarcopenic obesity. Subjects include 2,287 males and females aged 60 and older without diagnosed diabetes from the National Health and Nutrition Examination Survey (NHANES 1999-2004). Body composition measurements indicating waist circumference and appendicular skeletal muscle mass, measured by dual-energy x-ray absorptiometry (DXA), were utilized to construct four body composition categories-healthy, sarcopenic non-obese, non-sarcopenic obese and sarcopenic obese. Physical functioning was measured using self-reports of difficulty performing six activities. The homeostasis model assessment (IR(HOMA)) was used to measure insulin resistance, while inflammatory state was assessed through measurement of serum C-reactive protein. Modified Poisson regression models were used to examine the association between physical functioning and body composition, and to evaluate whether differences in insulin resistance or inflammation partially explained this relationship. In the analysis we controlled for possible confounders such as age, education, sex, height and race/ethnicity. Findings suggest that physical functioning problems are increased in those with sarcopenic obesity, sarcopenic non-obesity and non-sarcopenic obesity. Furthermore, these associations may be influenced by differences in insulin resistance among different body composition phenotypes. |
| | |
Authors:
|
Me Canon; Em Crimmins |
Related Documents
:
|
7960193 - Glycerol toxicity for human peritoneal mesothelial cells in culture: comparison with gl... 22284633 - Nyggf4 as a new therapeutic target for obesity-associated insulin resistance. 3284873 - Postexercise dose-response relationship between plasma glucose and insulin secretion. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-07 |
Journal Detail:
|
Title: Obesity (Silver Spring, Md.) Volume: - ISSN: 1930-7381 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089-0191. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Obesity, Insulin resistance and Alzheimer's Disease.
Next Document: Teammates and social influence affect weight loss outcomes in ateam-based weight loss competition.