Document Detail

Impact of IgE-mediated hypersensitivity on nasal mucociliary clearance.
MedLine Citation:
PMID:  20713757     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of IgE-mediated hypersensitivity on mucociliary clearance time (MCCT) and clinical severity, as indicated by total nasal symptoms score (TNSS) and peak expiratory flow index (PEFI). DESIGN: A prospective cross-sectional study. SETTING: Tertiary medical center. PARTICIPANTS: One hundred twenty-nine patients with rhinitis and 48 healthy control subjects. MAIN OUTCOME MEASURES: Results of an allergy skin prick test in the patients with rhinitis categorized them as allergic (AR) or nonallergic (non-AR). We evaluated TNSS and PEFI in the patient group and assessed MCCTs from the patients in the rhinitis groups and the healthy controls. RESULTS: The AR group patients had the longest MCCT, followed by patients in the non-AR group and the healthy controls (mean MCCTs, 14.36, 10.87, and 6.55 minutes, respectively). The AR group patients had significantly higher TNSS and worse PEFI compared with patients in the non-AR group (P = .002 and P = .03, respectively). We found a significant positive correlation of MCCTs with TNSS, and MCCTs showed a tendency to be inversely correlated with PEFI (rho = 0.43 [P < .001] and r = -0.22 [P = .05], respectively). In AR group patients, the wheal responses to Dermatophagoides pteronyssinus, Dermatophagoides farinae, American cockroach, and Bermuda grass were fairly correlated with the MCCTs (r = 0.39 [P = .001], r = 0.40 [P = .001], r = 0.34 [P = .01], and r = 0.36 [P = .02], respectively). The maximal wheal response among various positive allergen responses was well correlated with the MCCTs (r = 0.54 [P < .001]). CONCLUSION: A prolonged MCCT, significant correlation between MCCTs and the magnitude of allergen reactivity, and clinical severity suggest an impact of IgE-mediated hypersensitivity on mucociliary clearance function.
Virat Kirtsreesakul; Pornpanitan Somjareonwattana; Suwalee Ruttanaphol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  136     ISSN:  1538-361X     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  801-6     Citation Subset:  AIM; IM    
Division of Allergy and Rhinology, Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
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MeSH Terms
Antigens / diagnostic use,  immunology
Cross-Sectional Studies
Immunoglobulin E / blood*
Intradermal Tests
Middle Aged
Mucociliary Clearance / immunology*
Nasal Polyps / immunology
Peak Expiratory Flow Rate / immunology*
Prospective Studies
Rhinitis, Allergic, Perennial / diagnosis,  immunology*
Statistics as Topic
Young Adult
Reg. No./Substance:
0/Antigens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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