Document Detail

Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children.
MedLine Citation:
PMID:  24959779     Owner:  NLM     Status:  In-Data-Review    
introduction and objective. Mast cells (MC) are effector cells during severe systemic reactions (SR) to Hymenoptera stings. Venom specific immunotherapy (VIT) is the treatment of choice for prevention of SR to stings. Tryptase and prostaglandin D2 metabolites (PGD2) are the markers of MC activation. The study design was to 1. compare baseline values of serum tryptase concentration (BST) and PGD2 metabolites in children with/without venom sensitization, 2. to evaluate an influence of rush VIT on MC markers in treated children. materials and methods. Sensitized group: 25 children with SR to Hymenoptera sting. Control group: 19 healthy children. Active treatment: 5-day-rush-VIT. BST was evaluated by ImmunoCAP, PGD2 metabolites in blood and urine by GC-NICI-MS. results. The baseline blood levels of MC markers were significantly higher, while urinary concentration of 9α,11β-PGF2 was significantly lower in the whole group of venom-sensitized children compared to controls. Severity of SR showed negative correlation with urinary PGD2 metabolites, while positive with plasma 9α,11β-PGF2 and BST concentration The highest sensitivity was obtained for plasma 9α,11β-PGF2 whereas the highest specificity for urinary PGD-M. conclusions. In children with IgE-mediated SR to Hymenoptera stings, elevation of baseline values of PGD2 metabolites in blood is accompanied by decreased excretion of its urinary metabolites. Assessment of stable PGD2 metabolites might serve as an independent MC marker to identify allergic children. There is an association between urinary PGD2 metabolites and severity of the SR to Hymenoptera stings.
Ewa Cichocka-Jarosz; Marek Sanak; Andrzej Szczeklik; Piotr Brzyski; Jacek J Pietrzyk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of agricultural and environmental medicine : AAEM     Volume:  21     ISSN:  1898-2263     ISO Abbreviation:  Ann Agric Environ Med     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9500166     Medline TA:  Ann Agric Environ Med     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  294-301     Citation Subset:  IM    
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