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The Impact of High- Dose Chemotherapy, Autologous Stem Cell Transplantation and Conventional Chemotherapy on Quality of life of Long Term Survivors with Follicular Lymphoma.
MedLine Citation:
PMID:  21864036     Owner:  NLM     Status:  Publisher    
Summary Background: In this study we investigated quality of life (QoL) of long term survivors with follicular lymphoma (FL) after high-dose chemotherapy (HDCT) and autologus stem cell transplantation (ASCT) with two standardized questionnaires. Methods: Altogether, 124 patients with FL were included in the study. A total of 63 patients received HDCT with ASCT, this group was compared with 61 patients who were treated with Rituximab and CHOP chemotherapy and supplementary radiation. In addition, QoL of the patients was compared to QoL of healthy people on the basis of two studies about the general health status of the German population. Results: When QoL of the HDCT group and the conventional therapy group were compared, there was a tendency for a better QoL in the HDCT group, maybe due to a higher proportion of patients in CR or a longer follow up period in the HDCT group (8.5 years vs. 4.5 years in the conventional therapy group). In both the HDCT group and the conventional therapy group, the results of the questionnaires show a reduced QoL compared to the healthy population. Conclusion: In this study, there was a tendency for a better QoL in the HDCT group compared to the conventional therapy group. However, the negative impact of both HDCT and conventional therapy on QoL of patients with follicular lymphoma should not be underestimated and should lead to the development of less toxic therapy strategies.
Silke Andresen; Juliane Brandt; Sascha Dietrich; Marie-Luise Memmer; Anthony D Ho; Mathias Witzens-Harig
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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