Document Detail

Impact of HMG-CoA reductase inhibitors for non-treated coronary segments.
MedLine Citation:
PMID:  15819300     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: HMG-CoA reductase inhibitors (statin) have been reported to decrease coronary artery events in several angiographic studies. However, the mechanism by which statin achieve this is still unclear. The purpose of this study was to identify the effect of statin on coronary plaque using serial intravascular ultrasound analysis. METHODS AND RESULTS: In this study, 48 patients with 48 lesions were divided into the prescribed group (statin group, n = 22) or the non-prescribed group (control group, n = 26) after successful coronary artery stenting. IVUS images were obtained at consecutive 5 mm segments, 5 mm from the proximal stent edge, immediately after stenting and at 6 months follow up. External elastic membrane volume (EEMV), lumen volume (LV) and plaque volume (PV) were measured using Simpson's method. The control group revealed no significant serial change in EEMV, PV, and LV during 6 months. On the other hand, the statin group revealed significant reductions of PV (35.5 +/- 12.7 mm3 vs 30.9 +/- 15.6 mm3, p = 0.001), resulting in increase of LV (47.7 +/- 19.8 mm3 vs 52.5 +/- 22.2 mm3, p = 0.003) without EEMV change (82.8 +/- 21.8 mm3 vs 83.9 +/- 25.7 mm3, p = NS). Although percent EEMV and percent LV changes showed no differences between the two groups, a larger percent PV change was observed in the statin group compared to the control group (control; 5.8 +/- 20.3% vs statin; -20.4 +/- 21.8%, p = 0.02). CONCLUSION: The results of this study suggest that statin administration for 6 months reduces coronary plaque without positive vessel remodeling.
Hiroki Nishioka; Kenei Shimada; Toru Kataoka; Makoto Hirose; Koichiro Asawa; Takao Hasegawa; Hajime Yamashita; Shoichi Ehara; Kimio Kamimori; Tsunemori Sakamoto; Yoshiki Kobayashi; Takayoshi Yoshimura; Minoru Yoshiyama; Kazuhide Takeuchi; Junichi Yoshikawa
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Osaka city medical journal     Volume:  50     ISSN:  0030-6096     ISO Abbreviation:  Osaka City Med J     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376413     Medline TA:  Osaka City Med J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, Japan.
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MeSH Terms
Carotid Stenosis / drug therapy*,  ultrasonography*
Coronary Vessels / drug effects*,  ultrasonography*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Treatment Outcome
Ultrasonography, Interventional*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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