| Impact of gluten withdrawal on health-related quality of life in celiac subjects: an observational case-control study. | |
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MedLine Citation:
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PMID: 20588037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD). PATIENTS AND METHODS: We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD. RESULTS: At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls. CONCLUSIONS: At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception. |
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Authors:
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Gian Eugenio Tontini; Emanuele Rondonotti; Valeria Saladino; Simone Saibeni; Roberto de Franchis; Maurizio Vecchi |
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Publication Detail:
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Type: Journal Article Date: 2010-06-24 |
Journal Detail:
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Title: Digestion Volume: 82 ISSN: 1421-9867 ISO Abbreviation: Digestion Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 221-8 Citation Subset: IM |
Affiliation:
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University of Milan, Milan, Italy. gianeugeniotontini@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Celiac Disease / diet therapy* Diet, Gluten-Free* Female Humans Male Middle Aged Quality of Life* Questionnaires Severity of Illness Index Statistics, Nonparametric Treatment Outcome |
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