Document Detail

Impact of gluten withdrawal on health-related quality of life in celiac subjects: an observational case-control study.
MedLine Citation:
PMID:  20588037     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD).
PATIENTS AND METHODS: We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD.
RESULTS: At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls.
CONCLUSIONS: At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.
Gian Eugenio Tontini; Emanuele Rondonotti; Valeria Saladino; Simone Saibeni; Roberto de Franchis; Maurizio Vecchi
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Publication Detail:
Type:  Journal Article     Date:  2010-06-24
Journal Detail:
Title:  Digestion     Volume:  82     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  221-8     Citation Subset:  IM    
University of Milan, Milan, Italy.
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MeSH Terms
Case-Control Studies
Celiac Disease / diet therapy*
Diet, Gluten-Free*
Middle Aged
Quality of Life*
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome

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