Document Detail

Impact of gestational hypertension on left ventricular function and geometric pattern.
MedLine Citation:
PMID:  21389638     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of gestational hypertension on left ventricular (LV) function in previously normotensive young women has not been evaluated.
METHODS AND RESULTS: A total of 106 gestational hypertensive women (GHW, 32.3 ± 4.2 years) and 93 normotensive pregnant women (NPW, 30.2 ± 4.4 years) were enrolled. Transthoracic echocardiography, including 2-dimensional strain echocardiography, was done and myocardial performance (Tei index), LV mass index (LVMI), and relative wall thickness (RWT) were analyzed. GHW had significantly increased wall thickness (interventricular septum, 9.5 ± 0.9 mm vs. 8.8 ± 1.0 mm, P < 0.001; posterior wall, 9.0 ± 1.1 mm vs. 8.5 ± 1.1 mm, P = 0.007; and RWT, 0.39 ± 0.06 vs. 0.35 ± 0.05, P = 0.02), higher LVMI (95.6 ± 17.3g/m² vs. 86.1 ± 14.5g/m², P = 0.03), longer isovolumetric relaxation time (117.7 ± 18.2 ms vs. 82.3 ± 12.6 ms, P = 0.003), lower E/A ratio (1.00 ± 0.29 vs. 1.27 ± 0.33, P = 0.002), and higher Tei index (0.48 ± 0.23 vs. 0.33 ± 0.13, P = 0.003) compared to NPW. Global longitudinal LV strain, representing LV systolic function, was also significantly reduced in GHW compared with NPW (-17.6 ± 2.95% vs. -21.2 ± 2.14%, P = 0.02). A total of 62% of GHW (n = 66) had abnormal geometry, of whom, 42 (40%) had eccentric hypertrophy (EH). A total of 93% of NPW (n = 86) had normal geometry, and only 7 NPW (7%) had abnormal geometry.
CONCLUSIONS: GHW had aggravated diastolic and longitudinal systolic dysfunction. GHW had increased LVMI with the abnormal geometric pattern of EH. The reversibility of these morphological and functional impairments after delivery needs to be clarified.
Kyoung-Im Cho; Seong-Man Kim; Mi-Seung Shin; Eui-Joo Kim; Eun-Joo Cho; Hae-Sun Seo; Sung-Hee Shin; Se-Jung Yoon; Jung-Hyun Choi
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Publication Detail:
Type:  Journal Article     Date:  2011-03-07
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-25     Completed Date:  2011-09-29     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1170-6     Citation Subset:  IM    
Division of Cardiology, Maryknoll Medical Center, Busan, Korea.
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MeSH Terms
Cardiomegaly / etiology*,  pathology
Echocardiography, Stress
Heart Function Tests
Hypertension, Pregnancy-Induced / pathology*,  physiopathology*,  ultrasonography
Ventricular Function, Left / physiology*
Young Adult
Comment In:
Circ J. 2011;75(5):1055-6   [PMID:  21467661 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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