| Impact of Family History of Coronary Artery Disease in Young Individuals (from the CONFIRM Registry). | |
| | |
MedLine Citation:
|
PMID: 23411105 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Although family history (FH) of coronary artery disease (CAD) is considered a risk factor for future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with FH of CAD have been inadequately studied. From 27,125 consecutive patients who underwent coronary computed tomographic angiography, 6,308 young patients (men aged <55 years and women aged <65 years) without known CAD were identified. Obstructive CAD was defined as >50% stenosis in a coronary artery >2 mm diameter. Risk-adjusted logistic regression, Kaplan-Meier, and Cox proportional-hazards models were used to compare patients with and without FH of CAD. Compared with subjects without FH of CAD, those with FH of CAD (FH+) had higher prevalences of any CAD (40% vs 30%, p <0.001) and obstructive CAD (11% vs 7%, p <0.001), with multivariate odds of FH+ increasing the likelihood of obstructive CAD by 71% (p <0.001). After a mean follow-up period of 2 ± 1 years (42 myocardial infarctions and 39 all-cause deaths), FH+ patients experienced higher annual rates of myocardial infarction (0.5% vs 0.2%, log-rank p = 0.001), with a positive FH the strongest predictor of myocardial infarction (hazard ratio 2.6, 95% confidence interval 1.4 to 4.8, p = 0.002). In conclusion, young FH+ patients have higher presence, extent, and severity of CAD, which are associated with increased risk for myocardial infarction. Compared with other clinical CAD risk factors, positive FH in young patients is the strongest clinical predictor of future unheralded myocardial infarction. |
| | |
Authors:
|
Yuka Otaki; Heidi Gransar; Daniel S Berman; Victor Y Cheng; Damini Dey; Fay Y Lin; Stephan Achenbach; Mouaz Al-Mallah; Matthew J Budoff; Filippo Cademartiri; Tracy Q Callister; Hyuk-Jae Chang; Kavitha Chinnaiyan; Benjamin J W Chow; Augustin Delago; Martin Hadamitzky; Joerg Hausleiter; Philipp Kaufmann; Erica Maffei; Gilbert Raff; Leslee J Shaw; Todd C Villines; Allison Dunning; James K Min |
Related Documents
:
|
11471345 - Technical developments in cardiac ct: 2000 update. 23147435 - Short and long term outcome of percutaneous coronary intervention with drug eluting ste... 17599455 - Detection of phrenic nerves and their relation to cardiac anatomy using 64-slice multid... 20696295 - Cardiac and pericardial calcifications on chest radiographs. 9503175 - Interventional cardiology in europe 1994. working group coronary circulation of the eur... 8069015 - Role of mb isoforms (isomers) in the early diagnosis of acute myocardial infarction. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-11 |
Journal Detail:
|
Title: The American journal of cardiology Volume: - ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2013 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, California; Department of Medicine, Cedars-Sinai Heart Institute, Los Angeles, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relation of Patients Living Without a Partner or Spouse to Being Physically Active After Acute Coron...
Next Document: Association Among Leukocyte Count, Mortality, and Bleeding in Patients With Non-ST-Segment Elevation...