| Impact of FDG PET/CT in the staging and the follow-up of anal carcinoma. | |
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MedLine Citation:
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PMID: 21061012 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: The purpose of the study was to assess the diagnostic performance of positron emission tomography/computed tomography and fluorodeoxyglucose (18F) (FDG PET/CT) for the staging and the follow-up of anal carcinoma, and to evaluate the impact of FDG PET/CT on patient management. MATERIALS AND METHODS: Patients with anal carcinoma were referred to our department from October 2004 until July 2008. The diagnostic performance was evaluated on a perexamination basis and on a per-site basis, together with impact of PET/CT on patient management. The standard of truth was histology when available and, in all cases, follow-up data during at least 6 months. RESULTS: Fifty-eight FDG PET/CT performed in 44 patients were analysed—22 for initial staging and 36 during follow-up. The detection rate of non-excised tumours on initial examination was 93%. During post-treatment follow-up, FDG PET/CT had, on a per-examination basis, sensitivity for the detection of persistent or recurrent disease of 93% and specificity of 81%, and on a per-site basis, 86% and 97%, respectively. Its negative predictive value was 94% on a per-examination basis and 98% on a per-site basis. FDG PET/CT had an impact on management in nine patients out of 44 (20%), which was relevant in eight of them (89%). CONCLUSION: FDG PET/CT is an accurate imaging modality in anal cancer. It has an interesting added value during post-treatment follow-up, especially when persistence or recurrence of disease is suspected. Further studies are needed to evaluate whether surveillance by means of FDG PET/CT might have a positive impact on overall survival. |
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Authors:
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Laetitia Vercellino; Françoise Montravers; Vincent de Parades; Virginie Huchet; Khaldoun Kerrou; Pierre Bauer; Emmanuel Touboul; Jean-Noël Talbot |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of colorectal disease Volume: 26 ISSN: 1432-1262 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 201-10 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Department, Hôpital Tenon et Université Pierre et Marie Curie, Paris, France. laetitiasika@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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