Document Detail

The Impact of Exercise Training on Liver Transplanted Familial Amyloidotic Polyneuropathy (FAP) Patients.
MedLine Citation:
PMID:  23211558     Owner:  NLM     Status:  Publisher    
BACKGROUND: Liver transplantation is nowadays the only effective answer to adjourn the outcome of functional limitations associated with familial amyloidotic polyneuropathy (FAP), a neurodegenerative disease characterized by sensory and motor polyneuropathies. Nevertheless, there is a detrimental impact associated with the after-surgery period on the fragile physical condition of these patients. Exercise training has been proven to be effective on reconditioning patients after transplantation. However, the effects of exercise training in liver transplanted FAP patients have not been scrutinized yet. METHODS: The study aimed to evaluate the effects of a 24-week exercise training program (supervised or home-based) on body composition, muscle strength, and walking capacity of liver transplanted FAP patients. To fulfill this goal, a sample corresponding to 33% of all FAP patients who undergone a liver transplantation in the area of Lisbon between January 2006 and December 2008 were followed over time. Three evaluation periods were accomplished: M1 (pre-exercise training period), M2 (immediate post-exercise training period), and M3 (24 weeks after M2). The former allowed an assessment of the impact of detraining in these patients. RESULTS: The exercise training program improved body composition (lean mass and total body skeletal muscle mass), weight, and walking capacity. The improvements were more pronounced within the patients with supervised exercise training compared with the patients on the home-based program. In general, the benefits of the exercise training perdure even after a 24-week detraining period. CONCLUSIONS: Exercise training results in significant improvements on the physical condition of liver transplanted FAP patients.
Maria Teresa Tomás; Helena Santa-Clara; Paula Marta Bruno; Estela Monteiro; Margarida Carrolo; Eduardo Barroso; Luís B Sardinha; Bo Fernhall
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Transplantation     Volume:  -     ISSN:  1534-6080     ISO Abbreviation:  Transplantation     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, Technical University of Lisbon, Cruz-Quebrada, Portugal. 2 Sciences and Technologies of Rehabilitation, Lisbon Higher School of Health Technology, Polytechnic Institute of Lisbon, Lisbon, Portugal. 3 Division of Mathematics, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, Technical University of Lisbon, Cruz-Quebrada, Portugal. 4 Hepatobiliopancreatic and Transplantation Center, Hospital Curry Cabral, Lisbon, Portugal. 5 Exercise and Cardiovascular Research Laboratory, Kinesiology and Community Health Department, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL. 6 Address correspondence to: Maria Teresa Tomás, PhD, Sciences and Technologies of Rehabilitation Department, Lisbon Higher School of Health Technology, Polytechnique Institute of Lisbon, Av. D. João II, Lote 4.69.01, 1990-096 Lisbon, Portugal.
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