Document Detail


Impact of ethanol on the developing GABAergic system.
MedLine Citation:
PMID:  19943346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.
Authors:
Ricardo Noboro Isayama; Paulo Emilio Correa Leite; Jean Pierre Mendes Lima; Daniela Uziel; Edna Nanami Yamasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  292     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1922-39     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Affiliation:
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Alcohol-Induced Disorders, Nervous System / metabolism,  pathology,  physiopathology*
Animals
Cell Movement / drug effects
Cell Proliferation / drug effects
Central Nervous System Depressants / toxicity
Disease Models, Animal
Ethanol / toxicity*
Female
Mice
Neural Inhibition / drug effects,  physiology
Neural Pathways / drug effects,  embryology,  growth & development
Neurogenesis / drug effects,  physiology
Neurons / drug effects,  metabolism
Pregnancy
Prenatal Exposure Delayed Effects / metabolism,  pathology,  physiopathology*
Telencephalon / drug effects*,  embryology*,  growth & development
gamma-Aminobutyric Acid / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 56-12-2/gamma-Aminobutyric Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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