| The impact of elevated blood glycemic level of patients with type 2 diabetes mellitus on the erythrocyte membrane: FTIR study. | |
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MedLine Citation:
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PMID: 20652761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In developed countries, medical awareness about the disease and how to deal with it is less acknowledged. With diabetes mellitus the situation becomes more serious due to the fact that it affects nearly all parts of the body and may lead to loss of vision. In this study, the variation of blood glucose level of type 2 diabetic patients was considered, and its effect(s) on their blood erythrocyte membranes was studied by Fourier transform infrared spectroscopy. Patients with type 2 diabetes mellitus were classified into two groups with mean fasting blood glucose level of 185 mg/dl (D-185 group) and 285 mg/dl (D-285 group). For comparison, healthy individuals were involved where their mean fasting blood glucose level is 86 mg/dl. Type 2 diabetes mellitus was found to induce change in the lipid and protein components and causing some important structural changes in the protein secondary structure with change in the beta-sheet and beta-turn structures at D-285 mg/dl group. Erythrocyte membrane disorder was increased associated with restriction in the vibrational motion around the phospholipids interface region. |
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Authors:
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Sherif S Mahmoud |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell biochemistry and biophysics Volume: 58 ISSN: 1559-0283 ISO Abbreviation: Cell Biochem. Biophys. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9701934 Medline TA: Cell Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: IM |
Affiliation:
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Biophysics and Laser Science Unit, Research Institute of Ophthalmology, PO Box 90, Giza, Egypt. sheri_sm@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Blood Proteins / chemistry Cell Membrane / ultrastructure Cohort Studies Diabetes Mellitus, Type 2 / blood*, physiopathology Erythrocytes / chemistry, pathology*, ultrastructure Humans Hyperglycemia / blood* Protein Structure, Secondary Spectroscopy, Fourier Transform Infrared* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Blood Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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