| Impact of Dual-Time-Point F-18 FDG PET/CT in the Assessment of Pleural Effusion in Patients With Non-Small-Cell Lung Cancer. | |
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MedLine Citation:
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PMID: 21552017 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: : The aim of this study was to assess the utility of dual-time-point F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) in differentiating benign from malignant pleural disease, in patients with non-small-cell lung cancer. METHODS: : A total of 61 patients with non-small-cell lung cancer and pleural effusion were included in this retrospective study. All patients had whole-body FDG PET/CT imaging at 60 ± 10 minutes post-FDG injection, whereas 31 patients had second-time delayed imaging repeated at 90 ± 10 minutes for the chest. Maximum standardized uptake values (SUVmax) and the average percent change in SUVmax (%SUV) between time point 1 and time point 2 were calculated. Malignancy was defined using the following criteria: (1) visual assessment using 3-points grading scale; (2) SUVmax ≥2.4; (3) %SUV ≥ +9; and (4) SUVmax ≥2.4 and/or %SUV ≥ +9. Analysis of variance test and receiver operating characteristic analysis were used in statistical analysis. P < 0.05 was considered significant. RESULTS: : Follow-up revealed 29 patient with malignant pleural disease and 31 patients with benign pleural effusion. The average SUVmax in malignant effusions was 6.5 ± 4 versus 2.2 ± 0.9 in benign effusions (P < 0.0001). The average %SUV in malignant effusions was +13 ± 10 versus -8 ± 11 in benign effusions (P < 0.0004). Sensitivity, specificity, and accuracy for the 5 criteria were as follows: (1) 86%, 72%, and 79%; (2) 93%, 72%, and 82%; (3) 67%, 94%, and 81%; (4) 100%, 94%, and 97%. CONCLUSIONS: : Dual-time-point F-18 FDG PET can improve the diagnostic accuracy in differentiating benign from malignant pleural disease, with high sensitivity and good specificity. |
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Authors:
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Khaled Alkhawaldeh; Hans-J Biersack; Anna Henke; Samer Ezziddin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 423-8 Citation Subset: IM |
Affiliation:
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From the Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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