| Impact of dietary genistein and aging on executive function in rats. | |
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MedLine Citation:
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PMID: 19945528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genistein is an estrogenic soy isoflavone widely promoted for healthy aging, but its effects on cognitive function are not well-understood. We examined the cognitive effects of once daily oral genistein treatment at two doses (approximately 162 microg/kg/day low dose and a 323 microg/kg/day high dose) in ovariectomized young (7 month), middle-aged (16 month), and old (22 month) Long-Evans rats. Operant tasks including delayed spatial alternation (DSA), differential reinforcement of low rates of responding (DRL), and reversal learning that tap prefrontal cortical function were used to assess working memory, inhibitory control/timing, and strategy shifting, respectively. At the conclusion of cognitive testing, brains were collected and relative densities of D1 and D2 dopamine receptors and dopamine transporter (DAT) were measured in the prefrontal cortex. On the DSA task, the high dose old group performed worse than both the high dose young and middle-aged groups. On the DRL task, the high dose of genistein resulted in a marginally significant impairment in the ratio of reinforced to non-reinforced lever presses. This effect was present across age groups. Age effects were also found as old rats performed more poorly than the young and middle-aged rats on the DSA overall. In contrast, middle-aged and old rats made fewer lever presses on the DRL than did the young rats, a pattern of behavior associated with better performance on this task. Moreover, while DAT levels overall decreased with age, genistein treatment produced an increase in DAT expression in old rats relative to similarly aged control rats. D1 and D2 densities did not differ between genistein dose groups or by age. These results highlight the fact that aspects of executive function are differentially sensitive to both genistein exposure and aging and suggest that altered prefrontal dopamine function could potentially play a role in mediating these effects. |
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Authors:
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Steven L Neese; Victor C Wang; Daniel R Doerge; Kellie A Woodling; Juan E Andrade; William G Helferich; Donna L Korol; Susan L Schantz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2009-11-27 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 32 ISSN: 1872-9738 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-15 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 200-11 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Veterinary Sciences, University of Illinois at Urbana-Champaign, 2001 S Lincoln Avenue, Urbana, IL 61802, USA. stlneese@illinois.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Brain Chemistry / drug effects Cognition Disorders / chemically induced*, physiopathology Disability Evaluation Dopamine / metabolism Dose-Response Relationship, Drug Executive Function / drug effects*, physiology Female Food, Formulated / adverse effects Genistein / toxicity* Memory, Short-Term / drug effects, physiology Neuropsychological Tests Neurotoxicity Syndromes / physiopathology Phytoestrogens / toxicity Prefrontal Cortex / drug effects*, metabolism, physiopathology Rats Rats, Long-Evans Receptors, Dopamine / drug effects, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG024387/AG/NIA NIH HHS; P01 AG024387-010003/AG/NIA NIH HHS; T32 ES007326/ES/NIEHS NIH HHS; T32 ES007326-09/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phytoestrogens; 0/Receptors, Dopamine; 446-72-0/Genistein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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