| Impact of Diabetes Mellitus on Long-term Clinical Outcomes of Patients on Chronic Hemodialysis after Percutaneous Coronary Intervention. | |
| | |
MedLine Citation:
|
PMID: 22010995 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: End-stage renal disease (ESRD) is known to correlate with poor outcome in patients undergoing percutaneous coronary intervention (PCI). This study examines the impact of diabetes mellitus (DM) on the long-term outcome of patients with ESRD on chronic hemodialysis. Methods: A cohort of patients with ESRD on chronic hemodialysis, who underwent PCI with drug-eluting stents, was followed for 1 year. The clinical outcome in this population was compared retrospectively based on the presence of DM. Major adverse cardiac events (MACE) as the composite of all-cause death, Q-wave myocardial infraction and target lesion revascularization (TLR), as well as TLR as an individual outcome, were the main end points of the study. Results: In the study cohort (n = 198), 48.5% had DM. Diabetic patients were more commonly female. The lesion characteristics were similar between groups except for more frequent saphenous vein graft intervention in nondiabetics. At 1-year follow-up there was no difference in the rate of MACE between diabetic and nondiabetic patients (40.4% vs. 39.3%, respectively, p = 0.89), driven primarily by a very high mortality rate (1-year overall mortality of 33.5%). After adjustment for the relevant clinical co-variables, DM was not associated with the composite end point. However, diabetic patients had a significantly higher incidence of 1-year TLR compared to nondiabetics (13.8% vs. 3.6%, respectively, p = 0.04). Conclusion: The prognosis of patients with ESRD after PCI is dismal with a very high overall mortality rate regardless of the presence of DM. Patients with ESRD appear to be at higher risk for the need of revascularization. (J Interven Cardiol 2011;**:1-9). |
| | |
Authors:
|
Gabriel L Sardi; Gabriel Maluenda; Rebecca Torguson; Zhenyi Xue; William O Suddath; Kenneth M Kent; Joseph Lindsay; Lowell F Satler; Augusto D Pichard; Ron Waksman |
Related Documents
:
|
20595135 - Perioperative management of diabetes and hyperglycemia in patients undergoing orthopaed... 20051615 - Wireless solutions for managing diabetes: a review and future prospects. 21123165 - Diabetes mellitus reduces activity of human udp-glucuronosyltransferase 2b7 in liver an... 17615485 - Control and disordered eating in type 1 diabetes. 10869785 - Correction of hyperinsulinemia in oligoovulatory women with clomiphene-resistant polycy... 12793595 - Diet and exercise in the prevention of diabetes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
|
Title: Journal of interventional cardiology Volume: - ISSN: 1540-8183 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
©2011 Wiley Periodicals, Inc. |
Affiliation:
|
Washington Hospital Center, Washington, DC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis of In2O3@SiO2 Core-shell Nanoparticles with Enhanced Deeper Energy Level Emissions of In2O...
Next Document: Preceding intravenous thrombolysis facilitates endovascular mechanical recanalization in large intra...