| Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. | |
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MedLine Citation:
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PMID: 21774611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer. |
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Authors:
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Jill Hardin; Iona Cheng; John S Witte |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-07-20 |
Journal Detail:
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Title: Nutrition and cancer Volume: 63 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-12 Completed Date: 2011-12-27 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 860-72 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of California at San Francisco, San Francisco, California 94158-9001, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carotenoids Case-Control Studies Cereals* Data Collection Diet* Energy Intake Food Habits Fruit* Glycemic Index* Humans Interviews as Topic Male Middle Aged Odds Ratio Prostatic Neoplasms / epidemiology* Questionnaires Risk Factors Vegetables* |
| Grant Support | |
ID/Acronym/Agency:
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CA88164/CA/NCI NIH HHS; CA98683/CA/NCI NIH HHS; R01 CA088164-11/CA/NCI NIH HHS; R01 CA098683-06/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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36-88-4/Carotenoids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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