Document Detail

Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk.
MedLine Citation:
PMID:  21774611     Owner:  NLM     Status:  MEDLINE    
Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer.
Jill Hardin; Iona Cheng; John S Witte
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-20
Journal Detail:
Title:  Nutrition and cancer     Volume:  63     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-12-27     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  860-72     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Data Collection
Energy Intake
Food Habits
Glycemic Index*
Interviews as Topic
Middle Aged
Odds Ratio
Prostatic Neoplasms / epidemiology*
Risk Factors
Grant Support
CA88164/CA/NCI NIH HHS; CA98683/CA/NCI NIH HHS; R01 CA088164/CA/NCI NIH HHS; R01 CA088164-11/CA/NCI NIH HHS; R01 CA098683-06/CA/NCI NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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