Document Detail

The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism.
MedLine Citation:
PMID:  22571552     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperthyroidism is associated with unpleasant symptoms and hypertension due to increased adrenergic tone. Therefore, beta-blockers are often used in hyperthyroid patients. While some beta-blockers (such as propronolol and metoprolol) may have unwanted effects on lipid profile, carvedilol, a new alpha- and beta-blocker, has been suggested to have some metabolic advantages with respect to lipid profiles in hypertensive patients. However, this has not been shown in hyperthyroid patients.
OBJECTIVE: We aimed to compare the effects of two beta-blockers (metoprolol and carvedilol) on the lipid profiles of hyperthyroid patients with hypertension.
METHODS: Thirty patients with hyperthyroidism and hypertension were randomly assigned to receive either carvedilol (n = 15) or metoprolol (n = 15). Thyroid-stimulating hormone (TSH), free T3, free T4, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and total cholesterol levels were measured before and following 3 months of treatment.
RESULTS: Systolic and diastolic blood pressure, heart rate, TSH, and free T4 improved significantly in both treatment groups. There were no statistically significant changes in the lipid parameters in either of the two treatment groups; however, triglyceride levels slightly decreased with carvedilol treatment. There were also no differences between the two groups in terms of the typical symptoms of hyperthyroidism.
CONCLUSION: Carvedilol might be a preferred agent to treat hyperthyroid patients who have hypertension and dyslipidemia. This is likely due to the possible beneficial effect of carvedilol on lipid parameters, especially on triglyceride levels.
Sabahattin Ozbilen; Mehmet Ali Eren; Mehmet Nuri Turan; Tevfik Sabuncu
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-05-09
Journal Detail:
Title:  Endocrine research     Volume:  37     ISSN:  1532-4206     ISO Abbreviation:  Endocr. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-10-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Department of Internal Medicine, Harran University Faculty of Medicine, Sanliurfa, Turkey.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Blood Pressure / drug effects
Carbazoles / therapeutic use*
Heart Rate / drug effects
Hypertension / blood,  complications,  drug therapy*
Hyperthyroidism / complications*
Lipids / blood*
Metoprolol / therapeutic use*
Middle Aged
Propanolamines / therapeutic use*
Thyrotropin / blood
Thyroxine / blood
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Lipids; 0/Propanolamines; 0K47UL67F2/carvedilol; 37350-58-6/Metoprolol; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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