Document Detail

The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III).
MedLine Citation:
PMID:  20696989     Owner:  NLM     Status:  MEDLINE    
Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years). When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently associated with wave reflections, with stronger associations observed in younger individuals. The impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections is strongly dependent on age and is largely driven by blood pressure. Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population.
Carmel M McEniery; Yasmin; Kaisa M Maki-Petaja; Barry J McDonnell; Margaret Munnery; Stacey S Hickson; Stanley S Franklin; John R Cockcroft; Ian B Wilkinson;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-09
Journal Detail:
Title:  Hypertension     Volume:  56     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-10-29     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
Aged, 80 and over
Aorta / pathology,  physiopathology*
Blood Glucose / analysis
Blood Pressure / physiology*
Cardiovascular Diseases / blood,  diagnosis,  physiopathology*
Cholesterol / blood
Middle Aged
Multivariate Analysis
Pulsatile Flow
Risk Factors
Triglycerides / blood
Vascular Resistance / physiology
Young Adult
Grant Support
FS/07/001/21990//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 97C5T2UQ7J/Cholesterol

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