| The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III). | |
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MedLine Citation:
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PMID: 20696989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years). When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently associated with wave reflections, with stronger associations observed in younger individuals. The impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections is strongly dependent on age and is largely driven by blood pressure. Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population. |
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Authors:
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Carmel M McEniery; Yasmin; Kaisa M Maki-Petaja; Barry J McDonnell; Margaret Munnery; Stacey S Hickson; Stanley S Franklin; John R Cockcroft; Ian B Wilkinson; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-09 |
Journal Detail:
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Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 591-7 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Box 110, Hills Rd, Cambridge CB2 0QQ, UK. cmm41@cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Aging* Aorta / pathology, physiopathology* Blood Glucose / analysis Blood Pressure / physiology* Cardiovascular Diseases / blood, diagnosis, physiopathology* Cholesterol / blood Electrocardiography Female Humans Male Middle Aged Multivariate Analysis Pulsatile Flow Pulse Risk Factors Triglycerides / blood Vascular Resistance / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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