Document Detail

Impact of cardiometabolic risk factors on major cardiovascular events in patients with familial combined hyperlipidemia.
MedLine Citation:
PMID:  23018766     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Familial combined hyperlipidemia (FCH) is an inherited lipid disorder associated with premature cardiovascular disease. It has not been established whether the cardiometabolic risk factors, which frequently accompany FCH, such as diabetes, metabolic syndrome (MetS) and hypertension, modulate cardiovascular risk in FCH patients.
METHODS AND RESULTS: In this single-center, retrospective study, 695 FCH patients with adequate follow-up were enrolled (mean age, 48.9 years; 455 male). Risk factors including lipid levels were evaluated before the initiation of treatment. Acute myocardial infarction (AMI) and cardiovascular death were recorded during a mean follow-up of 9 years. The combined endpoint (AMI and/or cardiovascular death) occurred in 41 patients (5.9% of the total). Those FCH patients who reached the combined endpoint had lower high-density lipoprotein cholesterol (HDL-C) than those who did not, but levels of other lipid variables were similar. Presence of hypertension, diabetes or MetS was a predictor of the combined endpoint on univariate Kaplan-Meier analysis (all P<0.005). Multivariate Cox proportional analysis showed that hypertension and MetS were associated with the combined endpoint independently of age, gender, HDL-C and presence of coronary artery disease at enrollment (adjusted hazard ratios [HRs], 3.00; 95% confidence interval [CI]: 1.46-6.17, P=0.003; HR, 2.43; 95CI%: 1.11-5.33, P=0.026, respectively).
CONCLUSIONS: Cardiometabolic risk factors such as hypertension and MetS are independent predictors of major cardiovascular events in FCH patients.
Ioannis Skoumas; Constantina Masoura; Konstantinos Aznaouridis; Vassiliki Metaxa; Athanassios Tsokanis; Lambros Papadimitriou; Dimitrios Tousoulis; Christos Pitsavos; Christodoulos Stefanadis
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-09-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
First Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Age Factors
Cholesterol, HDL / blood*
Coronary Artery Disease* / blood,  etiology,  mortality
Diabetes Mellitus* / blood,  etiology,  mortality
Hyperlipidemia, Familial Combined* / blood,  complications,  mortality
Hypertension* / blood,  etiology,  mortality
Middle Aged
Myocardial Infarction* / blood,  etiology,  mortality
Retrospective Studies
Sex Factors
Reg. No./Substance:
0/Cholesterol, HDL

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