Document Detail

Impact of CPAP interface and mandibular advancement device on upper airway mechanical properties assessed with phrenic nerve stimulation in sleep apnea patients.
MedLine Citation:
PMID:  22772315     Owner:  NLM     Status:  Publisher    
Oronasal mask (ONM) can be used when mouth leaks impair nasal-CPAP effectiveness. However, ONM's constraint on the chin and straps' traction may alter upper airway (UA) mechanical properties. In contrast, mandibular advancement device associated with nasal-CPAP (NM+MAD) may reduce UA resistance. The aim of this exploratory study was to compare the effects of ONM, NM, and NM+MAD on UA mechanical properties. The three interface modalities were assessed in 11 OSAS patients at 6, 8, 10 cmH(2)O CPAP using a phrenic nerve magnetic stimulation protocol (PNMS). PNMS-twitches'related flow, pharyngeal pressures (nasopharynx, velopharynx, oropharynx) and UA resistances were determined. Regardless of CPAP level, twitch-induced maximum flow was higher with NM+MAD than with ONM. Velopahryngeal resistance was higher with ONM than with NM+MAD. Oropharyngeal resistance was higher with ONM than with NM. In conclusion, NM+MAD reduced velopharyngeal resistance compared to those measured with ONM and NM alone. We hypothesize that this strategy may help reducing the effective pressure level and thus further limit the risk for mouth leaks.
Jean-Christian Borel; Simon Gakwaya; Jean-François Masse; Cesar Augusto Melo-Silva; Frédéric Sériès
Related Documents :
22533655 - Effect of the rs168924 single-nucleotide polymorphism in the slc6a2 catecholamine trans...
25154345 - The physiological effects and quality of chest compressions during cardiopulmonary resu...
18065485 - Mechanical dyssynchrony by 3d echo correlates with acute haemodynamic response to biven...
22658785 - Randomized crossover study of neurally adjusted ventilatory assist in preterm infants.
8781755 - Prevalence of hypertension and rate of blood pressure control as assessed by home blood...
17194725 - Ho-1 induction lowers blood pressure and superoxide production in the renal medulla of ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Unité de recherche en pneumologie, Centre de recherche, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval. Québec, QC, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypoxia induced changes in lung fluid balance in humans is associated with beta-2 adrenergic recepto...
Next Document:  Reduced Expression of Psoriasin in Human Airway Cystic Fibrosis Epithelia.