| Impact of CPAP on asthmatic patients with obstructive sleep apnoea. | |
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MedLine Citation:
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PMID: 17050561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied. A prospective study was performed comparing the changes in airway responsiveness and quality of life in stable asthmatic OSA patients, before and 6 weeks after their nocturnal CPAP treatment. A total of 20 subjects (11 males and nine females) participated in the study. With the nocturnal CPAP treatment, the apnoea/hypopnoea index dropped from 48.1 +/- 23.6 x h(-1) to 2.6 +/- 2.5 x h(-1). There were no significant changes in airway responsiveness after CPAP treatment (provocative concentration causing a 20% fall in forced expiratory volume in one second (FEV(1); PC(20) 2.5 mg x mL(-1) (1.4-4.5)) compared with baseline (PC(20) 2.2 mg x mL(-1) (1.3-3.5)). There was no significant change in FEV(1) either. However, the asthma quality of life of the subjects improved from 5.0 +/- 1.2 at baseline to 5.8 +/- 0.9 at the end of the study. In conclusion, nocturnal continuous positive airway pressure treatment did not alter airway responsiveness or forced expiratory volume in one second in subjects with stable mild-to-moderate asthma and newly diagnosed obstructive sleep apnoea. However, nocturnal continuous positive airway pressure treatment did improve asthma quality of life. |
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Authors:
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C Lafond; F Sériès; C Lemière |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-18 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 29 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-31 Completed Date: 2007-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 307-11 Citation Subset: IM |
Affiliation:
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Sacre-Coeur Hospital, University of Montreal, Montreal, Quebec City, QC, Canada. chantal.lafond@umontreal.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asthma / complications, therapy* Continuous Positive Airway Pressure / methods* Female Humans Male Middle Aged Night Care Quality of Life Respiratory System Sleep Apnea, Obstructive / complications* Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2007 Feb;29(2):226-8
[PMID:
17264319
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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