Document Detail

Impact of C-reactive protein on in-stent restenosis: a meta-analysis.
MedLine Citation:
PMID:  20200627     Owner:  NLM     Status:  MEDLINE    
We sought to evaluate the impact of C-reactive protein (CRP) levels on in-stent restenosis after percutaneous coronary intervention.The plasma level of CRP is considered a risk predictor for cardiovascular diseases. However, the relationship between CRP and in-stent restenosis has been a matter of controversy. Meta-analysis reduces variability and better evaluates the correlation.We performed a systemic search for literature published in March 2008 and earlier, using MEDLINE(R), the Cochrane clinical trials database, and EMBASE(R). We also scanned relevant reference lists and hand-searched all review articles or abstracts from conference reports on this topic. Of the 245 studies that we initially searched, we chose 9 prospective observational studies (1,062 patients).Overall, CRP concentration was higher in patients who experienced in-stent restenosis. The weighted mean difference in CRP levels between the patients with in-stent restenosis and those without was 1.67, and the Z-score for overall effect was 2.12 (P=0.03). Our subgroup analysis that compared patients with stable and unstable angina showed a weighted mean difference in the CRP levels of 2.22 between the patients with and without in-stent restenosis, and the Z-score for overall effect was 2.23 (P=0.03) in 5 studies of unstable-angina patients. There was no significance in 4 studies of stable-angina patients.In spite of significant heterogeneity across the studies, our meta-analysis suggests that preprocedurally elevated levels of CRP are associated with greater in-stent restenosis after stenting and that this impact appears more prominent in unstable-angina patients.
Jian-Jun Li; Yi Ren; Ke-Ji Chen; Alan C Yeung; Bo Xu; Xin-Min Ruan; Yue-Jin Yang; Ji-Lin Chen; Run-Lin Gao
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  37     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-20     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-57     Citation Subset:  IM    
Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical College, Beijing 100037, China.
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MeSH Terms
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*
Biological Markers / blood
C-Reactive Protein / metabolism*
Coronary Artery Disease / blood,  diagnosis,  therapy*
Coronary Restenosis / blood*,  etiology
Middle Aged
Risk Assessment
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein
Comment In:
Tex Heart Inst J. 2010;37(1):40-1   [PMID:  20200625 ]

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