| Impact of blood pressure and blood pressure change during middle age on the remaining lifetime risk for cardiovascular disease: the cardiovascular lifetime risk pooling project. | |
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MedLine Citation:
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PMID: 22184621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Prior estimates of lifetime risk (LTR) for cardiovascular disease (CVD) examined the impact of blood pressure (BP) at the index age and did not account for changes in BP over time. We examined how changes in BP during middle age affect LTR for CVD, coronary heart disease, and stroke. METHODS AND RESULTS: Data from 7 diverse US cohort studies were pooled. Remaining LTRs for CVD, coronary heart disease, and stroke were estimated for white and black men and women with death free of CVD as a competing event. LTRs for CVD by BP strata and by changes in BP over an average of 14 years were estimated. Starting at 55 years of age, we followed up 61 585 men and women for 700 000 person-years. LTR for CVD was 52.5% (95% confidence interval, 51.3-53.7) for men and 39.9% (95% confidence interval, 38.7-41.0) for women. LTR for CVD was higher for blacks and increased with increasing BP at index age. Individuals who maintained or decreased their BP to normal levels had the lowest remaining LTR for CVD, 22% to 41%, compared with individuals who had or developed hypertension by 55 years of age, 42% to 69%, suggesting a dose-response effect for the length of time at high BP levels. CONCLUSIONS: Individuals who experience increases or decreases in BP in middle age have associated higher and lower remaining LTR for CVD. Prevention efforts should continue to emphasize the importance of lowering BP and avoiding or delaying the incidence of hypertension to reduce the LTR for CVD. |
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Authors:
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Norrina Allen; Jarett D Berry; Hongyan Ning; Linda Van Horn; Alan Dyer; Donald M Lloyd-Jones |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2011-12-19 |
Journal Detail:
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Title: Circulation Volume: 125 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-04 Completed Date: 2012-02-24 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: AIM; IM |
Affiliation:
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Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1102, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Pressure* / physiology Cardiovascular Diseases / epidemiology*, etiology, physiopathology Cohort Studies Female Follow-Up Studies Humans Hypertension / complications, epidemiology*, physiopathology Life Tables* Longitudinal Studies Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R21 HL085375/HL/NHLBI NIH HHS; R21 HL085375-02/HL/NHLBI NIH HHS; T32 HL 069771-07/HL/NHLBI NIH HHS; T32 HL069771-07/HL/NHLBI NIH HHS; U01 HL080295/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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