| The impact of biomechanics in tissue engineering and regenerative medicine. | |
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MedLine Citation:
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PMID: 19583462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. |
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Authors:
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David L Butler; Steven A Goldstein; Robert E Guldberg; X Edward Guo; Roger Kamm; Cato T Laurencin; Larry V McIntire; Van C Mow; Robert M Nerem; Robert L Sah; Louis J Soslowsky; Robert L Spilker; Robert T Tranquillo |
Publication Detail:
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Type: Historical Article; Journal Article; Review |
Journal Detail:
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Title: Tissue engineering. Part B, Reviews Volume: 15 ISSN: 1937-3376 ISO Abbreviation: Tissue Eng Part B Rev Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-08 Completed Date: 2010-05-26 Revised Date: 2011-11-07 |
Medline Journal Info:
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Nlm Unique ID: 101466660 Medline TA: Tissue Eng Part B Rev Country: United States |
Other Details:
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Languages: eng Pagination: 477-84 Citation Subset: IM |
Affiliation:
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Biomedical Engineering, University of Cincinnati , Cincinnati, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics History, 20th Century History, 21st Century Humans Regenerative Medicine / history, methods*, trends Tissue Engineering / history, methods*, trends |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR051336-01/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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