| Impact of atrial fibrillation on outcome of patients with idiopathic dilated cardiomyopathy: data from the Heart Muscle Disease Registry of Trieste. | |
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MedLine Citation:
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PMID: 20682760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: There is a paucity and inconsistency of data regarding the natural history of patients affected by idiopathic dilated cardiomyopathy (IDCM) and atrial fibrillation (AF). We examined the prognostic implications of AF in a subset of patients with IDCM. METHODS: We analyzed the data of 539 patients with IDCM enrolled in the Heart Muscle Disease Registry of Trieste. RESULTS: At baseline, 52 (9.6%) of 539 patients had AF. There was no difference in survival of patients with either AF or sinus rhythm at enrollment (P = .28). During long-term follow-up (90 ± 58 months), AF was detected on ECG/ECG-Holter monitoring in 28 (5.7%) of 487 patients in sinus rhythm at baseline. Predictors of new onset of AF at multivariate analysis were a more dilated left atrium (OR 1.35, 95% CI 1.06-1.72; P = .01) and a lower left ventricle ejection fraction (for 10% decrease, OR 2.41, 95% CI 1.24-4.69, P = .016). Patients developing AF had higher mortality/heart transplantation rate compared to patients who maintained sinus rhythm during follow-up (P < .001). At multivariate analysis, new onset AF (HR 3.67, 95% CI 2.07-6.5; P < .001) in the first three years after diagnosis, but not baseline AF, was found to be independently associated with a worse outcome. CONCLUSIONS: Atrial fibrillation is relatively frequent in patients with IDCM. The early development of AF during follow-up, but not its presence at baseline, is associated with poor survival. |
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Authors:
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Aneta Aleksova; Marco Merlo; Massimo Zecchin; Gastone Sabbadini; Giulia Barbati; Giancarlo Vitrella; Andrea Di Lenarda; Gianfranco Sinagra |
Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Clinical medicine & research Volume: 8 ISSN: 1554-6179 ISO Abbreviation: Clin Med Res Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-23 Completed Date: 2011-04-08 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101175887 Medline TA: Clin Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 142-9 Citation Subset: IM |
Affiliation:
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Cardiovascular Department, Ospedali Riuniti, University of Trieste, Trieste, Italy. aaleksova@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Fibrillation / complications, diagnosis, mortality*, physiopathology*, surgery Cardiomyopathy, Dilated / complications, mortality*, physiopathology*, surgery Disease-Free Survival Electrocardiography Female Follow-Up Studies Heart Transplantation Humans Italy Male Middle Aged Registries* Stroke Volume Survival Rate Transplantation, Homologous |
| Comments/Corrections | |
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