| Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases. | |
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MedLine Citation:
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PMID: 22577887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Data from several laboratories have shown that ethanol (EtOH) feeding impairs many essential methylation reactions that contribute to alcoholic liver disease (ALD). EtOH is also a comorbid factor in the severity of hepatitis C virus-induced liver injury. The presence of viral proteins further exacerbates the methylation defects to disrupt multiple pathways that promote the pathogenesis of liver disease. This review is a compilation of presentations that linked the methylation reaction defects with proteasome inhibition, decreased antigen presentation, and impaired interferon (IFN) signaling in the hepatocytes and dysregulated TNFα expression in macrophages. Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance. |
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Authors:
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Kusum K Kharbanda; Fawzia Bardag-Gorce; Shirish Barve; Patricia E Molina; Natalia A Osna |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-11 |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: - ISSN: 1530-0277 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 by the Research Society on Alcoholism. |
Affiliation:
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Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Internal Medicine, Biochemistry & Molecular Biology, Omaha, Nebraska. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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