| Impact of Airway Gas Exchange on the Multiple Inert Gas Elimination Technique: Theory. | |
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MedLine Citation:
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PMID: 20058188 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The multiple inert gas elimination technique (MIGET) provides a method for estimating alveolar gas exchange efficiency. Six soluble inert gases are infused into a peripheral vein. Measurements of these gases in breath, arterial blood, and venous blood are interpreted using a mathematical model of alveolar gas exchange (MIGET model) that neglects airway gas exchange. A mathematical model describing airway and alveolar gas exchange predicts that two of these gases, ether and acetone, exchange primarily within the airways. To determine the effect of airway gas exchange on the MIGET, we selected two additional gases, toluene and m-dichlorobenzene, that have the same blood solubility as ether and acetone and minimize airway gas exchange via their low water solubility. The airway-alveolar gas exchange model simulated the exchange of toluene, m-dichlorobenzene, and the six MIGET gases under multiple conditions of alveolar ventilation-to-perfusion, [Formula: see text], heterogeneity. We increased the importance of airway gas exchange by changing bronchial blood flow, [Formula: see text]. From these simulations, we calculated the excretion and retention of the eight inert gases and divided the results into two groups: (1) the standard MIGET gases which included acetone and ether and (2) the modified MIGET gases which included toluene and m-dichlorobenzene. The MIGET mathematical model predicted distributions of ventilation and perfusion for each grouping of gases and multiple perturbations of [Formula: see text] and [Formula: see text]. Using the modified MIGET gases, MIGET predicted a smaller dead space fraction, greater mean [Formula: see text], greater log(SD(VA)), and more closely matched the imposed [Formula: see text] distribution than that using the standard MIGET gases. Perfusion distributions were relatively unaffected. |
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Authors:
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Joseph C Anderson; Michael P Hlastala |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-1-8 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: - ISSN: 1521-6047 ISO Abbreviation: - Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Bioengineering, University of Washington, Box 355061, Seattle, WA, 98195-5061, USA, clarkja@u.washington.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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