| Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide. | |
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MedLine Citation:
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PMID: 21263118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aging has been recently associated with increased retrograde and oscillatory shear in peripheral conduit arteries, a hemodynamic environment that favors a proatherogenic endothelial cell phenotype. We evaluated whether nitric oxide (NO) bioavailability in resistance vessels contributes to age-related differences in shear rate patterns in upstream conduit arteries at rest and during rhythmic muscle contraction. Younger (n=11, age 26 ± 2 years) and older (n=11, age 61 ± 2 years) healthy subjects received intra-arterial saline (control) and the NO synthase inhibitor N(G)-Monomethyl-L-arginine. Brachial artery diameter and velocities were measured via Doppler ultrasound at rest and during a 5-minute bout of rhythmic forearm exercise. At rest, older subjects exhibited greater brachial artery retrograde and oscillatory shear (-13.2 ± 3.0 s(-1) and 0.11 ± .0.02 arbitrary units, respectively) compared with young subjects (-4.8 ± 2.3 s(-1) and 0.04 ± 0.02 arbitrary units, respectively; both P<0.05). NO synthase inhibition in the forearm circulation of young, but not of older, subjects increased retrograde and oscillatory shear (both P<0.05), such that differences between young and old at rest were abolished (both P>0.05). From rest to steady-state exercise, older subjects decreased retrograde and oscillatory shear (both P<0.05) to the extent that no exercise-related differences were found between groups (both P>0.05). Inhibition of NO synthase in the forearm circulation did not affect retrograde and oscillatory shear during exercise in either group (all P>0.05). These data demonstrate for the first time that reduced NO bioavailability in the resistance vessels contributes, in part, to age-related discrepancies in resting shear patterns, thus identifying a potential mechanism for increased risk of atherosclerotic disease in conduit arteries. |
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Authors:
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Jaume Padilla; Grant H Simmons; Paul J Fadel; M Harold Laughlin; Michael J Joyner; Darren P Casey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-24 |
Journal Detail:
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Title: Hypertension Volume: 57 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-04-14 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 484-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA. padillaja@missouri.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aging / physiology* Analysis of Variance Blood Flow Velocity / drug effects, physiology Brachial Artery / drug effects, physiology*, ultrasonography Enzyme Inhibitors / pharmacology Exercise / physiology* Humans Middle Aged Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Regional Blood Flow / physiology omega-N-Methylarginine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AR-55819/AR/NIAMS NIH HHS; F32 AR055819-01A1/AR/NIAMS NIH HHS; HL-093167/HL/NHLBI NIH HHS; HL-46493/HL/NHLBI NIH HHS; R01 HL036088-24/HL/NHLBI NIH HHS; R01 HL036088-25/HL/NHLBI NIH HHS; R01 HL046493-08/HL/NHLBI NIH HHS; R01 HL093167-01S1/HL/NHLBI NIH HHS; R01 HL093167-04/HL/NHLBI NIH HHS; RR-024150/RR/NCRR NIH HHS; T32-AR048523/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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