Document Detail


Impact of Age and Heterophilic Interference on the Basal Serum Tryptase, a Risk Indication for Anaphylaxis, in 1,092 Dermatology Patients.
MedLine Citation:
PMID:  22170044     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A raised baseline serum tryptase is a risk indicator for anaphylactic reactions, especially in patients with hymenoptera venom allergy. Borderline elevations (> 11.4 μg/l) occur frequently and may necessitate invasive diagnostic procedures to rule out systemic mastocytosis. We retrospectively analysed 1,092 non-mastocytotic patients from our general dermatology clinic with respect to age- and gender-associated effects and investigated the impact of heterophilic antibody interference on the tryptase assay. The results were stratified by gender and five age classes. Sera with raised tryptase (n = 106) were re-tested after pre-incubation with Heterophilic Blocking Tubes (HBT®, Scantibodies Laboratory; Santee, CA, USA). A significant increase in baseline tryptase was observed with increasing age. Incubation with HBT® caused a decline of more than 50% in only one care. In conclusion, older patients showed significantly higher serum tryptase levels and heterophilic interference was of subordinate relevance.
Authors:
Sibylle Schliemann; Florian Seyfarth; Uta-Christina Hipler; Peter Elsner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-15
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  -     ISSN:  0001-5555     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Dermatology and Allergology, University Hospital Jena, Friedrich-Schiller-University, DE-07743 Jena, Germany. E-mail: Schliemann@derma-jena.de.
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