Document Detail

The impact of acutely elevated intraocular pressure on the porcine optic nerve head.
MedLine Citation:
PMID:  21715357     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effects of acute elevations in intraocular pressure (IOP) on the cup, prelaminar, and lamina cribrosa regions of the porcine optic nerve head (ONH).
METHODS: Ex vivo imaging of 10 porcine ONHs was performed using spectral-domain optical coherence tomography (OCT). The IOP was manipulated with a pressure head and measured with a pressure transducer. Reference scans were taken at 0 mm Hg, before further scanning was performed at 7-mm Hg steps, up to 49 mm Hg. Morphometric parameters were measured across centrally located OCT B-scans at different IOPs, and the relationship between IOP and changes in these parameters was analyzed.
RESULTS: As IOP increased from 0 to 49 mm Hg, mean cross-sectional cup area increased (28% ± 3%, P < 0.001), lamina cribrosa area decreased (18% ± 2%, P < 0.001), and prelaminar tissue area decreased (5.5% ± 0.5%, P < 0.001). Multivariate regression demonstrated that most of the change in cup area is associated with changes in both lamina cribrosa position and thickness (r = 0.89, P < 0.001).
CONCLUSIONS: Acute elevations in IOP were shown to result in posterior displacement of ONH, as well as lamina cribrosa and prelaminar tissue deformation in the porcine ONH.
Naeem Fatehee; Paula K Yu; William H Morgan; Stephen J Cringle; Dao-Yi Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-03
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-04     Completed Date:  2011-10-14     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6192-8     Citation Subset:  IM    
Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Western Australia, Australia.
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MeSH Terms
Acute Disease
Glaucoma / physiopathology
Intraocular Pressure / physiology*
Ocular Hypertension / physiopathology*
Optic Disk / pathology*
Optic Nerve Diseases / diagnosis,  physiopathology*
Sus scrofa
Tomography, Optical Coherence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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