Document Detail

Impact of abdominopelvic CT on Ewing sarcoma management.
MedLine Citation:
PMID:  20634109     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: Abdominopelvic computed tomography (APCT) is often performed in patients with skeletal Ewing sarcoma family of tumors during initial staging and for subsequent clinical indications, such as metastasis surveillance; however, its clinical impact is unknown. The purpose of this study was to evaluate whether these computed tomographic examinations alter oncologic management and therefore patient outcomes.
MATERIALS AND METHODS: One hundred eight consecutive patients with skeletal Ewing sarcoma family of tumors seen from 1985 to 2008 were retrospectively reviewed to identify imaging workup, pathology, primary site, evidence of metastatic disease, and patient outcomes. Data were analyzed using Wilcoxon's rank sum tests.
RESULTS: Sixty-five of the 108 patients (60%) underwent 342 abdominopelvic computed tomographic examinations during a mean follow-up period of 8.9 years. During this time period, only one of the 65 patients (1.5%) who underwent APCT was discovered to have abdominal metastatic disease. There was no significant difference in the incidence of metastatic disease to the skeleton or chest between the groups without and with APCT (P = .10). There were 26 pelvic and lumbosacral primaries (24%) and 82 limb primaries (76%). Subgroup analysis performed on the 82 patients with limb primaries without (n = 36) and with (n = 46) APCT showed no significant differences in metastatic incidence to the skeleton or chest (P = .14).
CONCLUSIONS: This study indicates that APCT, associated with increased radiation exposure and health expenditure, has a limited role in initial staging and follow-up in patients with skeletal Ewing sarcoma, particularly in patients with limb primaries.
Matthew D Dobbs; Stefanie R Lowas; Marta Hernanz-Schulman; Ginger E Holt; Chang Yu; J Herman Kan
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Publication Detail:
Type:  Journal Article     Date:  2010-07-15
Journal Detail:
Title:  Academic radiology     Volume:  17     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1288-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 AUR. Published by Elsevier Inc. All rights reserved.
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
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MeSH Terms
Abdominal Neoplasms / epidemiology,  radiography*,  secondary*
Bone Neoplasms / epidemiology,  radiography*
Child, Preschool
Middle Aged
Pelvic Neoplasms / epidemiology,  radiography*,  secondary*
Radiography, Abdominal / utilization
Radiography, Thoracic / utilization
Reproducibility of Results
Risk Assessment
Risk Factors
Sarcoma, Ewing's / epidemiology,  radiography*,  secondary*
Sensitivity and Specificity
South Carolina / epidemiology
Tomography, X-Ray Computed / statistics & numerical data*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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