| Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond. | |
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MedLine Citation:
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PMID: 22836386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond. |
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Authors:
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Sébastien Foulquier; U Muscha Steckelings; Thomas Unger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-27 |
Journal Detail:
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Title: Current hypertension reports Volume: - ISSN: 1534-3111 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands, s.foulquier@maastrichtuniversity.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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