| Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients. | |
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MedLine Citation:
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PMID: 15599840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The long-term effects of carvedilol on muscle sympathetic nerve activity (MSNA) and muscle blood flow at rest and exercise in patients with chronic heart failure (CHF) remain unknown. METHODS AND RESULTS: Twenty-six patients (New York Heart Association class II-III) were randomized to carvedilol or placebo. Blood pressure, heart rate, MSNA, and forearm vascular resistance (FVR) at rest and during isometric forearm exercise (10% and 30% maximal voluntary contraction) were assessed before and after 6 months. Seven patients did not complete the study. Paired data were obtained in 19 (carvedilol 12, placebo 7). Carvedilol significantly decreased MSNA levels and heart rate at rest (-13 +/- 2 versus 3 +/- 8 bursts/min, P = .0001 and -16 +/- 3 vs -4 +/- 6 bpm, P = .05, respectively) and peak exercise (30% = -20 +/- 5 versus -3 +/- 7 bursts/min, P = 0.05 and -19 +/- 4 versus -4 +/- 6 bpm, P = 0.03, respectively) when compared with placebo. Carvedilol did not change a magnitude of response of MSNA and heart rate during exercise (-10 +/- 3 versus -7 +/- 2 bursts/min, P = 0.7 and 11 +/- 3 versus 6 +/- 1, P = .6, respectively). FVR was unchanged by carvedilol. When MSNA was quantified by burst incidence, the strength of reduction in MSNA was attenuated but still greater than placebo. CONCLUSIONS: Carvedilol reduces MSNA in patients with CHF. Carvedilol does not reduce FVR at rest or during isometric exercise. |
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Authors:
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Luciana D N J De Matos; Giulliano Gardenghi; Maria Urbana P B Rondon; Helena N Soufen; Adriana P Tirone; Antonio C P Barretto; Patrcia C Brum; Holly R Middlekauff; Carlos E Negrão |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiac failure Volume: 10 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-15 Completed Date: 2005-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 496-502 Citation Subset: IM |
Affiliation:
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Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology,
therapeutic use* Blood Pressure / drug effects Carbazoles / pharmacology, therapeutic use* Dose-Response Relationship, Drug Double-Blind Method Exercise / physiology* Exercise Test Female Heart Failure / drug therapy*, physiopathology Heart Rate / drug effects Humans Male Middle Aged Muscle, Skeletal / innervation* Peroneal Nerve / physiopathology* Propanolamines / pharmacology, therapeutic use* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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