| The Impact of 5,10-Methenyltetrahydrofolate Synthetase Polymorphism on Diabetic Nephropathy in the Taiwanese Population. | |
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MedLine Citation:
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PMID: 21895484 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Genome-wide association studies provide information implicating 5,10-methenyltetrahydrofolate synthetase (MTHFS) as a candidate gene for renal disease. In the Atherosclerosis Risk in Communities study, the intronic single-nucleotide polymorphism rs6495446 in the gene MTHFS confirmed the association between this gene and renal disease among Caucasian participants. We replicated this genetic association in a Taiwanese population with diabetic nephropathy (DN). A total of 358 Taiwanese patients with type 2 diabetes (T2D) were recruited. The case group comprised 180 T2D patients with DN, and the control group comprised the remaining patients without DN. rs6495446 in MTHFS had no significant effect on the risk of DN in Taiwanese patients with T2D. Multivariate logistic regression analysis demonstrated that being male, the duration of diabetes, plasma triglyceride level, and glycemic control were factors that predicted the development of DN. |
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Authors:
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Chin-Jung Lin; Min-Jie Wen; Yi-Jen Hung; Dee Pei; Shi-Wen Kuo; Chang-Hsun Hsieh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: - ISSN: 1945-0257 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital , Taipei, Taiwan, Republic of China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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