Document Detail

Impact of 4-methylbenzylidene camphor (4-MBC), daidzein and estrogen on intact and osteotomized bone in osteopenic rats.
MedLine Citation:
PMID:  21803835     Owner:  NLM     Status:  Publisher    
The study investigated influence of 4-methylbenzylidene camphor (4-MBC), daidzein (D) and estradiol-17β-benzoate (E2) on cancellous bone either intact or osteotomized in ovariectomized (Ovx) rats. Ovx three-month old rats were fed with soy free (SF) diet during 8 weeks, thereafter, bilateral transverse metaphyseal osteotomy of tibia was performed and rats were divided into groups: rats fed with SF, SF supplemented with 4-MBC (200mg), D (50mg) or E2 (0.4mg) per kg body weight. After 5 or 10 weeks, lumbar spine and tibia of 12 rats from each group underwent computed tomographical, biomechanical, histological, ashing analyses. 4-MBC and E2 improved bone parameters in lumbar spine and tibia; were not favorable for osteotomy healing; decreased serum osteocalcin level. Daidzein improved bone parameters to a lesser extend, however, facilitated osteotomy healing. Lumbar spine, BMD: 338+9, 346+5, 361+6, 360+5 mg/cm3 in SF, D, 4-MBC, E2 after 10w. Tibia, yield load: 98+5, 114+3, 90+2, 52+4 N, in SF, D, 4-MBC, E2 after 10w. Serum daidzein was 54+6 ng/mL in D group, equol was not detected. Alp and Igf-1 genes were down-regulated in callus after D and E2 compared to 4-MBC (week 5). The response of bone tissue and serum markers of bone metabolism could be ordered: D<4-MBC<E2. Treatments were more effective after 5w vs. 10 w. In SF group, bone structure was impaired after 5w, improved after 10w probably due to adaptation mechanisms to osteoporosis. Concluding, it is conceivable that 4-MBC may improve bone tissue in osteoporotic organism; osteoporotic patients with fractures could have benefit from daidzein treatment.
Marina Komrakova; Stephan Sehmisch; Mohammad Tezval; Ulrich Schmelz; Holm Frauendorf; Thomas Grueger; Thomas Wessling; Carolin Klein; Miriam Birth; Klaus Michael Stuermer; Ewa Klara Stuermer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-29
Journal Detail:
Title:  The Journal of endocrinology     Volume:  -     ISSN:  1479-6805     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
M Komrakova, Department of Trauma and Reconstructive Surgery, University of Goettingen, Goettingen, 37073, Germany.
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