Document Detail

Immunotoxicologic analysis of maternal transmission of asthma risk.
MedLine Citation:
PMID:  19404877     Owner:  NLM     Status:  MEDLINE    
Asthma has origins in early life. Epidemiological studies show that maternal, more than paternal, asthma significantly increases a child's risk of developing the disease. Experimental animal models exist which reproduce the increased susceptibility to asthma seen in human studies, and allow analysis of immunotoxic mechanisms that may contribute to neonatal allergy. In addition to maternal asthma, chemically-induced skin contact hypersensitivity or exposure during pregnancy of non-allergic females to certain environmental agents, e.g., air pollution particles, can also result in increased susceptibility to asthma in their offspring. We review here experimental models of maternal transmission of asthma risk, the progress to date in identifying mechanisms, and potential directions for future research.
Alexey V Fedulov; Lester Kobzik
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of immunotoxicology     Volume:  5     ISSN:  1547-6901     ISO Abbreviation:  J Immunotoxicol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-06-09     Revised Date:  2009-11-05    
Medline Journal Info:
Nlm Unique ID:  101201960     Medline TA:  J Immunotoxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-52     Citation Subset:  IM    
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Allergens / adverse effects
Asthma / chemically induced*,  embryology,  epidemiology,  etiology*
Environmental Pollutants / adverse effects
Maternal Exposure / adverse effects*
Risk Factors
Stress, Psychological / complications,  immunology
Reg. No./Substance:
0/Allergens; 0/Environmental Pollutants
Erratum In:
J Immunotoxicol. 2009 Mar;6(1):74

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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