| Immunotoxicity studies in mice exposed to methyl isocyanate. | |
| | |
MedLine Citation:
|
PMID: 3532429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of methyl isocyanate (MIC) on systemic immunity were evaluated in female B6C3F1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on four consecutive days. Humoral immunity, measured as the antibody response to sheep erythrocytes, and natural killer cell activity were not affected by MIC. Furthermore, resistance to the infectious agents Listeria monocytogenes, mouse malaria parasite, and influenza virus, or to B16F10 transplantable tumor cells, was not compromised by MIC exposure. Although lymphoproliferative responses to mitogens were not significantly suppressed, the response of splenic lymphocytes to allogeneic leukocytes in a mixed leukocyte response (MLR) was suppressed in a dose-related fashion and differed significantly from the control response at the 3-ppm level. These studies indicate that MIC exposure in mice does not severely alter systemic immunity. The moderate changes detected in immune function may be a secondary consequence of respiratory toxicity which occurred in these animals. |
| | |
Authors:
|
M I Luster; A N Tucker; D R Germolec; M T Silver; P T Thomas; S J Vore; J R Bucher |
Related Documents
:
|
1097519 - The enhancing effect of mitogens on the in vivo immune response of rabbits. 7343969 - Humoral immunity in japanese quail following surgical bursectomy at various ages. 640749 - Different suppressive effects of combined cyclophosphamide-antigen treatment compared w... 4125439 - Specific suppression of immune responses. 16335119 - Severe feed restriction enhances innate immunity but suppresses cellular immunity in ch... 8077609 - Acrylamide induced immunosuppression in rats and its modulation by 6-mfa, an interferon... 61969 - Immunofluorescence evidence for the absence of histone h1 in a mitotically dividing, ge... 6858079 - Hepatitis-associated markers in the american red cross blood donor population. v. preva... 804829 - Conifer pollen allergy: studies of immunogenicity and cross antigenicity of conifer pol... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Toxicology and applied pharmacology Volume: 86 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 1986 Oct |
Date Detail:
|
Created Date: 1986-11-14 Completed Date: 1986-11-14 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 140-4 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation / drug effects Atmosphere Exposure Chambers Cyanates / immunology* Female Hemolytic Plaque Technique Isocyanates* Killer Cells, Natural / drug effects Lung / drug effects*, immunology Mice |
| Chemical | |
Reg. No./Substance:
|
0/Cyanates; 0/Isocyanates; 624-83-9/methyl isocyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary react...
Next Document: Late-life migraine accompaniments--further experience.