Document Detail

Immunotoxic responses of cypermethrin, a synthetic pyrethroid insecticide in rats.
MedLine Citation:
PMID:  1506076     Owner:  NLM     Status:  MEDLINE    
The study was undertaken to evaluate immunotoxic effects of cypermethrin administered orally (in ground nut oil) to male albino rats at dose levels (mg/kg) of 0 (control), 5, 10, 20 and 40 once daily for 90 days. Cypermethrin administration produced a significant leucopenia at 40 mg/kg on day 90. A dose dependent decrease (P greater than 0.05) in delayed type hypersensitivity reaction was noticed on day 61 post treatment. Humoral response as evidenced by serum haemagglutinin and haemolysin titres did not show any definite pattern on day 90. However, a significant decrease in spleen weights and significant increase in adrenal weights was recorded in rats receiving the highest test level. Total body weights and liver weights did not show any significant change with any of the dose level studied. Results of the study reveal that low doses (5 and 10 mg/kg) did not have any adverse effect on the immuno-competence of rats.
C Varshneya; T Singh; L D Sharma; H S Bahga; S K Garg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  36     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-09-21     Completed Date:  1992-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Department of Pharmacology and Toxicology, College of Veterinary Sciences, G. B. Pant University of Agriculture & Technology, Pantnagar.
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MeSH Terms
Administration, Oral
Adrenal Glands / drug effects
Antibody Formation / drug effects*
Body Weight / drug effects
Dose-Response Relationship, Drug
Hemagglutinins / blood
Hemolysin Proteins / blood
Hypersensitivity, Delayed
Immunity, Cellular / drug effects*
Immunosuppressive Agents / toxicity*
Insecticides / administration & dosage,  toxicity*
Leukopenia / chemically induced*
Organ Size / drug effects
Pyrethrins / administration & dosage,  toxicity*
Rats, Inbred Strains
Spleen / drug effects
Reg. No./Substance:
0/Hemagglutinins; 0/Hemolysin Proteins; 0/Immunosuppressive Agents; 0/Insecticides; 0/Pyrethrins; 52315-07-8/cypermethrin

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