Document Detail

Immunotoxic effects of nickel in the mud crab Scylla serrata.
MedLine Citation:
PMID:  19046900     Owner:  NLM     Status:  MEDLINE    
The presence of xenobiotic contaminants especially metals in coastal waters is a major concern as they are immunotoxic to aquatic animals even at low concentrations. In our present study, mud crab Scylla serrata was exposed to three sublethal concentrations (0.4, 0.6 and 0.8 mg/L) of nickel for 30 days under laboratory conditions and the alterations of hematological parameters like haemocyte count, clotting time, haemocyte viability, protein content and immunomodulatory components like phenoloxidase, phagocytosis and superoxide anion generation were measured. In addition, the accumulation patterns of nickel were measured in gills, hepatopancreas and ovary. The accumulation was more in gills when compared to hepatopancreas and ovary of crabs exposed to nickel and was not detected in the control crabs. The results revealed a significant (P<0.05) induction of superoxide anion generation and phagocytosis activity in the haemolymph of the crabs exposed to nickel when compared to control. On the contrary, the rest of the parameters were significantly (P<0.05) reduced in the experimental groups when compared to the control. All the studied parameters exhibited a concentration dependent response.
K Vijayavel; S Gopalakrishnan; R Thiagarajan; H Thilagam
Publication Detail:
Type:  Journal Article     Date:  2008-03-04
Journal Detail:
Title:  Fish & shellfish immunology     Volume:  26     ISSN:  1095-9947     ISO Abbreviation:  Fish Shellfish Immunol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-10     Completed Date:  2009-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505220     Medline TA:  Fish Shellfish Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Institute for Ocean Management, Anna University, Chennai, Tamil Nadu, India.
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MeSH Terms
Brachyura / drug effects*,  immunology*
Immune System / drug effects
Immunotoxins / toxicity*
Lethal Dose 50
Nickel / toxicity*
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Immunotoxins; 0/Water Pollutants, Chemical; 7440-02-0/Nickel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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