| Immunotherapy with interleukin 2 after ABMT in AML. | |
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MedLine Citation:
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PMID: 8504274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myeloablative chemo (+/- radio) therapy and rescue with ABMT has been used as final consolidation therapy in 18 patients with AML in first remission. In seven (6 autologous, 1 syngeneic) marrow reinfusion was followed by iv IL-2. One patient, who commenced IL-2 4 days after BMT, died from pulmonary oedema due to the capillary leak syndrome. Thereafter, treatment with IL-2 was delayed until the platelet count reached 30 x 10(9)/l. All patients developed reversible hypotension (treated with infusion of colloid), but treatment was otherwise well tolerated. With 21-58 months (median 32 months) from the time of ABMT there has been one relapse (actuarial risk 17%, 95% confidence intervals (CI) 3-31%). The disease-free survival is 71% (95% CI 38-100%). Eleven patients with comparable remission induction and consolidation therapy, and an identical interval between diagnosis and ABMT (5-11 months, median 6 months) received an autograft without immunotherapy. With 24-45 months (median 29 months) follow-up the actuarial disease-free survival is 36% (95% CI 8-64%), the actuarial relapse risk is 54% (95% CI 18-90%). We conclude that immunotherapy given after ABMT to patients with AML in first remission when the platelet count exceeds 30 x 10(9)/l is safe and may induce an immunological environment which results in the elimination of residual leukaemia. |
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Authors:
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M D Hamon; H G Prentice; D J Gottlieb; I D Macdonald; J M Cunningham; O P Smith; M Gilmore; L Gandhi; C Collis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 11 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-08 Completed Date: 1993-07-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 399-401 Citation Subset: IM |
Affiliation:
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Department of Haematology, Royal Free Hospital and School of Medicine, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bone Marrow Transplantation* Combined Modality Therapy Humans Immunotherapy Interleukin-2 / therapeutic use* Leukemia, Myeloid, Acute / surgery, therapy* Middle Aged Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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