Document Detail

Immunotherapy with CTL peptide and VSSP eradicated established human papillomavirus (HPV) type 16 E7-expressing tumors.
MedLine Citation:
PMID:  16112257     Owner:  NLM     Status:  MEDLINE    
Peptide-based vaccines aimed at the induction of effective T-cell responses against established tumors have not been successful in clinic and require the use of new adjuvants. One of those is a new adjuvant in which gangliosides are incorporated into the outer membrane protein complex of Neisseria meningitidis to form very small size proteoliposomes (VSSP). In a preclinical model of human papillomavirus HPV16-induced cervical cancer we show that vaccination with HPV 16 E7 derived minimal CTL peptide and VSSP protects mice against tumor challenge, induces regression of established tumors and produces E7-specific CD8+ T-cell responses.
Isis Torréns; Osmany Mendoza; Aileen Batte; Osvaldo Reyes; Luis E Fernández; Circe Mesa; Gerardo Guillén
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Publication Detail:
Type:  Journal Article     Date:  2005-08-08
Journal Detail:
Title:  Vaccine     Volume:  23     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5768-74     Citation Subset:  IM    
Department of Cancer, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage
Cell Line
Mice, Inbred BALB C
Papillomaviridae / drug effects*,  immunology
Papillomavirus Infections / immunology,  therapy*
Peptide Fragments / administration & dosage,  immunology*
Proteolipids / administration & dosage*,  immunology
Tumor Virus Infections / immunology,  therapy*
Vaccines, Subunit / administration & dosage,  immunology
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Peptide Fragments; 0/Proteolipids; 0/Vaccines, Subunit; 0/proteoliposomes

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