| Immunotherapy throughout the decades: from Noon to now. | |
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MedLine Citation:
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PMID: 21055658 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To review major milestones in the development of subcutaneous allergen immunotherapy in 20-year segments. DATA SOURCES: Review of the literature available in textbooks and journals. STUDY SELECTION: Articles and books addressing major achievements in the development of subcutaneous allergy immunotherapy were selected for inclusion in this review. RESULTS: Immunotherapy administration has improved the lives of possibly millions of patients with hay fever. Asthmatic symptoms have been relieved if not ablated in millions as well. Insect venom hypersensitivity became treatable and highly effective. In the beginning years of immunotherapy, it was clear that immunotherapy worked; in the later years, the mechanisms for this efficacy were discovered. In this case, the therapy preceded its validation. Methods, materials, and safety have vastly improved. Postulated mechanisms explain much but not everything. CONCLUSIONS: There is still research to be accomplished, improvements to be made, and, of course, patients to be made well. |
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Authors:
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Ira Finegold; Robert J Dockhorn; Daniel Ein; William K Dolen; John Oppenheimer; Lawrence H Potter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 105 ISSN: 1534-4436 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 328-36; quiz 337, 358 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Allergy, St. Luke's-Roosevelt Hospital, New York, New York 10022, USA. drfinegold@AOL.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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