Document Detail

Immunotherapy throughout the decades: from Noon to now.
MedLine Citation:
PMID:  21055658     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To review major milestones in the development of subcutaneous allergen immunotherapy in 20-year segments.
DATA SOURCES: Review of the literature available in textbooks and journals.
STUDY SELECTION: Articles and books addressing major achievements in the development of subcutaneous allergy immunotherapy were selected for inclusion in this review.
RESULTS: Immunotherapy administration has improved the lives of possibly millions of patients with hay fever. Asthmatic symptoms have been relieved if not ablated in millions as well. Insect venom hypersensitivity became treatable and highly effective. In the beginning years of immunotherapy, it was clear that immunotherapy worked; in the later years, the mechanisms for this efficacy were discovered. In this case, the therapy preceded its validation. Methods, materials, and safety have vastly improved. Postulated mechanisms explain much but not everything.
CONCLUSIONS: There is still research to be accomplished, improvements to be made, and, of course, patients to be made well.
Ira Finegold; Robert J Dockhorn; Daniel Ein; William K Dolen; John Oppenheimer; Lawrence H Potter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  105     ISSN:  1534-4436     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-36; quiz 337, 358     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Department of Allergy, St. Luke's-Roosevelt Hospital, New York, New York 10022, USA.
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