Document Detail


Immunotherapy for metastatic melanoma.
MedLine Citation:
PMID:  22006439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Melanoma has traditionally been considered an immunogenic tumor. A number of approaches have been studied for enhancement of anti-tumor immunity. The first cytokine approved for the treatment of metastatic melanoma, interleukin-2, has resulted in prolonged responses in a small subset of patients, providing hope that immunotherapy might be useful for this disease. Ipilimumab, a monoclonal antibody to CTLA-4 was recently approved, and a number of other promising investigational approaches are currently being pursued. This manuscript discusses more recent advances in the treatment of melanoma employing a variety of immune-enhancing approaches. J. Cell. Biochem. © 2011 Wiley Periodicals, Inc.
Authors:
Christopher Zito; Harriet M Kluger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-17
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  -     ISSN:  1097-4644     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Yale Cancer Center, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06451.
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