Document Detail


Immunosurveillance as a regulator of tissue homeostasis.
MedLine Citation:
PMID:  23891238     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The immune system is intimately involved in the pathophysiology of several human disorders. Thus, excessive or chronic inflammation initiated by numerous insults exacerbates tissue damage and - at least in some settings - promotes oncogenesis. Nevertheless, immunosurveillance, the process whereby the immune system eliminates damaged, senescent and (pre-)malignant cells, appears to exert major homeostatic functions. Accumulating evidence indicates that defects in the molecular and cellular circuitries that underpin immune responses accelerate the course of chronic diseases, including hepatic cirrhosis and cancer. Along similar lines, the re-establishment of tissue homeostasis upon acute pathological insults such as ischemia appears to be delayed when normal immunological functions are naturally or experimentally compromised. Here, we propose that immunosurveillance is a key regulator of tissue homeostasis.
Authors:
Laura Senovilla; Lorenzo Galluzzi; Laurence Zitvogel; Guido Kroemer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-25
Journal Detail:
Title:  Trends in immunology     Volume:  -     ISSN:  1471-4981     ISO Abbreviation:  Trends Immunol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ltd.
Affiliation:
INSERM, U848, F-94805 Villejuif, France; INSERM, U1015, F-94805 Villejuif, France; Gustave Roussy, F-94805 Villejuif, France.
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