| Immunosuppressive treatment for juvenile myasthenia gravis. | |
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MedLine Citation:
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PMID: 1601015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The result of immunosuppressive treatment in 20 cases of generalized myasthenia gravis with onset before age 16 were analysed. The patients age at the beginning of immunosuppressive treatment ranged from 10 to 22 years. Thirteen patients suffered from a severe form of myasthenia gravis with respiratory attacks, the remaining 7 demonstrated a moderately severe form with bulbar symptoms dominating the clinical picture. Indication for immunosuppressive treatment was lack of or only slight improvement after thymectomy. Prednisone was used in 17 cases, high dosage of methylprednisolone in 8 (in one case twice), azathioprine in 11 and cyclophosphamide in 10. Best results were obtained with cyclophosphamide since significant improvement was recorded in 14/20 of patients. Corticosteroids, i.e. prednisone and high-dose methylprednisolone proved to be of limited value. |
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Authors:
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B Badurska; B Ryniewicz; H Strugalska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatrics Volume: 151 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-07-10 Completed Date: 1992-07-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 215-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical School Polish Academy of Sciences, Warsaw. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autoimmune Diseases / drug therapy* Azathioprine / therapeutic use Child Cyclophosphamide / therapeutic use Female Humans Immunosuppression* Immunosuppressive Agents / therapeutic use* Male Methylprednisolone / therapeutic use Myasthenia Gravis / drug therapy* Prednisone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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