Document Detail

Immunosuppressive treatment for juvenile myasthenia gravis.
MedLine Citation:
PMID:  1601015     Owner:  NLM     Status:  MEDLINE    
The result of immunosuppressive treatment in 20 cases of generalized myasthenia gravis with onset before age 16 were analysed. The patients age at the beginning of immunosuppressive treatment ranged from 10 to 22 years. Thirteen patients suffered from a severe form of myasthenia gravis with respiratory attacks, the remaining 7 demonstrated a moderately severe form with bulbar symptoms dominating the clinical picture. Indication for immunosuppressive treatment was lack of or only slight improvement after thymectomy. Prednisone was used in 17 cases, high dosage of methylprednisolone in 8 (in one case twice), azathioprine in 11 and cyclophosphamide in 10. Best results were obtained with cyclophosphamide since significant improvement was recorded in 14/20 of patients. Corticosteroids, i.e. prednisone and high-dose methylprednisolone proved to be of limited value.
B Badurska; B Ryniewicz; H Strugalska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  151     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-07-10     Completed Date:  1992-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  215-7     Citation Subset:  IM    
Department of Neurology, Medical School Polish Academy of Sciences, Warsaw.
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MeSH Terms
Autoimmune Diseases / drug therapy*
Azathioprine / therapeutic use
Cyclophosphamide / therapeutic use
Immunosuppressive Agents / therapeutic use*
Methylprednisolone / therapeutic use
Myasthenia Gravis / drug therapy*
Prednisone / therapeutic use
Reg. No./Substance:
0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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