| Immunosuppressive therapy is more effective than interferon in neuromyelitis optica. | |
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MedLine Citation:
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PMID: 17439893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine long-term treatment (LTT) of neuromyelitis optica (NMO), we retrospectively reviewed therapies of 26 patients with NMO followed in five French neurological departments. To assess LTT efficacy, the probability of relapse free after LTT was analysed. Patients were divided into two groups according to the first treatment receiving interferon beta (IFN Group, seven patients) or immunosuppressants (IS Group, 19 patients). The probability of relapse was significantly lower in the IS Group (P =0.0007). From our results, interferon beta is not recommended, and one of the best current therapeutic options for NMO appears to be immunosuppressants. |
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Authors:
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C Papeix; J-S Vidal; J de Seze; C Pierrot-Deseilligny; A Tourbah; B Stankoff; C Lebrun; T Moreau; P Vermersch; B Fontaine; O Lyon-Caen; O Gout |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-29 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 13 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-04-18 Completed Date: 2007-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 256-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Hôpital de la Salpêtrière, Paris, France. caroline.papeix@psl.ap-hop-paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Disease-Free Survival Female Humans Immunologic Factors / therapeutic use* Immunosuppressive Agents / therapeutic use* Interferon-beta / therapeutic use* Kaplan-Meiers Estimate Male Middle Aged Neuromyelitis Optica / drug therapy* Recurrence / prevention & control Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 0/Immunosuppressive Agents; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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