Document Detail


Immunosuppressive therapy for autoimmune inner ear disease.
MedLine Citation:
PMID:  19885385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune inner ear disease (AIED) is a rare disease that is diagnosed after clinical suspicion and response to corticosteroids. AIED manifests as progressive, bilateral, although often asynchronous, sensorineural hearing loss and can be associated with vestibular symptoms. Since its description as a defined disease entity in 1979, the initial mainstay of treatment remains high-dose corticosteroids. Several animal models have been developed to assist in determining efficacy of immunosuppression in AIED, and several clinical studies have also investigated the role of both steroid and steroid-sparing treatments. Here we discuss the basic science and clinical research surrounding the history of immunosuppressive therapy in AIED.
Authors:
Maria C Buniel; Katie Geelan-Hansen; Peter C Weber; Vincent K Tuohy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunotherapy     Volume:  1     ISSN:  1750-7448     ISO Abbreviation:  Immunotherapy     Publication Date:  2009 May 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2011-02-03     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101485158     Medline TA:  Immunotherapy     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use*
Autoimmune Diseases / drug therapy*,  immunology,  physiopathology
Biomedical Research
Hearing Loss, Sensorineural
Humans
Immunosuppressive Agents / therapeutic use*
Labyrinth Diseases / drug therapy*,  immunology,  physiopathology
Models, Animal
Grant Support
ID/Acronym/Agency:
DC-006422/DC/NIDCD NIH HHS; R01 DC006422/DC/NIDCD NIH HHS; R01 DC006422-01A2/DC/NIDCD NIH HHS; R01 DC006422-02/DC/NIDCD NIH HHS; R01 DC006422-03/DC/NIDCD NIH HHS; R01 DC006422-04/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents
Comments/Corrections

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